CRISPR Craze to Transform Cardiac Biology
نویسندگان
چکیده
منابع مشابه
Overview of CRISPR-Cas9 Biology.
Prokaryotes use diverse strategies to improve fitness in the face of different environmental threats and stresses, including those posed by mobile genetic elements (e.g., bacteriophages and plasmids). To defend against these elements, many bacteria and archaea use elegant, RNA-directed, nucleic acid-targeting adaptive restriction machineries called CRISPR -: Cas (CRISPR-associated) systems. Whi...
متن کاملCRISPR-Cas: biology, mechanisms and relevance
Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clustered regularly interspaced short palindromic repeats (CRISPR) and their associated proteins (Cas) display a prokaryotic adaptive immune system that memorizes previous infections by integrating short sequences of invading genomes-termed spacers-into the CRISPR locus. The spacers interspaced with ...
متن کاملApplication of CRISPR/Cas9 in plant biology
The CRISPR/Cas (clustered regularly interspaced short palindromic repeats/CRISPR-associated proteins) system was first identified in bacteria and archaea and can degrade exogenous substrates. It was developed as a gene editing technology in 2013. Over the subsequent years, it has received extensive attention owing to its easy manipulation, high efficiency, and wide application in gene mutation ...
متن کاملCraze initiation in glassy polymers
In this work a method is presented that can be used to predict craze initiation in glassy polymers. The approach is based on the view that the development of a craze is preceded by de formation of a localised plastic deformation zone. As this zone develops, the hydrostatic stress increases, and, when exceeding a critical stress level, cavitation will take place, leading to local development of ...
متن کاملCraze-Initiation Kinetics in Polystyrene
In this study it is shown, for a commercial polystyrene grade, that the strain-rate dependence of craze initiation is equivalent to that of yielding. This implies that the kinetics of craze initiation are determined by the nonlinear flow behavior, and that the actual cavitation process is governed by an additional, apparently rateindependent, criterion. © 2004 Wiley Periodicals, Inc. J Polym Sc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Molecular Medicine
سال: 2019
ISSN: 1471-4914
DOI: 10.1016/j.molmed.2019.06.008